The present invention relates to new N- aryl sulfonyl -3- substituted indole compounds, its derivative, its analog, its tautomer, its stereoisomer, its geometric isomer, its N- oxide, its polymorph, its pharmaceutically acceptable salt, its pharmaceutically acceptable solvate and contain its acceptable composition of drug. The present invention is more particularly directed to the new N- aryl sulfonyl -3- substituted indole compounds of logical formula (I), its derivative, its analog, its tautomer, its stereoisomer, its polymorph, its pharmaceutically acceptable salt, its pharmaceutically acceptable solvate and contain its acceptable composition of drug. The invention further relates to the preparation method, the acceptable purposes of composition and the compound and composition in medicine of the drug containing the compound that prepare logical formula (I) compound. The invention further relates to the new intermediates and preparation method that participate in the above process.本發明涉及新的N-芳基磺酰基-3-取代吲哚化合物、其衍生物、其類似物、其互變異構體、其立體異構體、其幾何異構體、其N-氧化物、其多晶形物、其藥物可接受的鹽、其藥物可接受的溶劑化物以及含有其的藥物可接受組合物。本發明特別涉及通式(I)的新的N-芳基磺酰基-3-取代吲哚化合物、其衍生物、其類似物、其互變異構體、其立體異構體、其多晶形物、其藥物可接受的鹽、其藥物可接受的溶劑化物以及含有其的藥物可接受組合物。本發明還涉及製備通式(I)化合物的製備方法、含有該化合物的藥物可接受組合物,以及該化合物和組合物在醫藥中的用途。本發明還涉及參與上述過程的新中間體和其製備方法。