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Method for determining the efficiency of the treatment with interferon beta (IFN beta) in a subject with esclerosismultiple that includes determining at least one gene expression regulated by interferon(IRG) and / or its variant
专利权人:
THE CLEVELAND CLINIC FOUNDATION
发明人:
RUDICK RICHARD A,RANSOHOFF RICHARD M.
申请号:
CL2012003571
公开号:
CL2012003571A1
申请日:
2012.12.18
申请国别(地区):
CL
年份:
2013
代理人:
摘要:
A method is provided for determining the efficacy of interferon-beta (IFN-&bgr;) therapy in a subject with multiple sclerosis. One step of the method can include obtaining a biological sample from the subject. After obtaining the biological sample, the expression level of at least one interferon-regulated gene (IRG) and/or variant thereof can be determined. Increased or decreased expression of the at least one IRG and/or variant thereof as compared to a control may indicate that the subject will respond poorly to IFN-&bgr; therapy.METODO PARA DETERMINAR LA EFICIENCIA DEL TRATAMIENTO CON INTERFERON BETA (IFN-BETA) EN UN SUJETO CON ESCLEROSISMULTIPLE QUE COMPRENDE DETERMINAR LA EXPRESION DE AL MENOS UN GEN REGULADO POR INTERFERON (IRG) Y/O SU VARIANTE
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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