Soi Khoon Yew;Ji Hoon Bae;Joon Ho Wang;Kelvin Hong Yap Koh;Hae-Ryong Song;Swee Hin Teoh
发明人:
Swee Hin Teoh,Hae-Ryong Song,Soi Khoon Yew,Kelvin Hong Yap Koh,Ji Hoon Bae,Joon Ho Wang
申请号：
US13124161
公开号：
US08702808B2
申请日:
2009.10.19
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Bioresorbable scaffolds for bone engineering, such as repair of bone defects, particularly long bone defects, or augmentation of bone length are described. Scaffolds are porous and comprise multiple side channels. In one embodiment, scaffolds are made from layers of micro-filament meshes comprising polycaprolactone (PCL) or a PCL-composite sequentially laid in incremental 60 degrees of rotation to produce a 0/60/120 degree layering pattern, providing for the formation of interconnected pores. The scaffold can comprise a central channel filled, packed or infused with suitable agents such as bioactive agents. Furthermore, the scaffolds are stiff but yet fracture resistant and with sufficient bending, compressive and torsional strength suitable for bone engineering. The slow degradation of the scaffold is sufficient for the 3D matrix to maintain structure integrity and mechanical properties during the remodelling process.
