Analogue compounds of archaebacterial membrane lipids and liposomal compounds integrating such compounds

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专利权人:

Gildas Rethore;Tristan Montier;Thierry Benvegnu;Pascal Delepine;Pierre Lehn;Claude Ferec;Daniel Plusquellec;Mickaelle Scahet

发明人:

Thierry Benvegnu,Daniel Plusquellec,Gildas Rethore,Mickaelle Scahet,Claude Ferec,Tristan Montier,Pascal Delepine,Pierre Lehn

申请号：

US11792011

公开号：

US08088747B2

申请日:

2005.12.07

申请国别(地区):

US

年份:

2012

代理人:

摘要：

The invention relates to a compound of general formula (I): where X=0 or 1, Z=O, S or CH2, R1 and R2 independently=OH or OY, where Y=a protecting group, OR3, where R3=a monosaccharide or disaccharide group, A1-CH2—N+(CH3)3, X′, where X=halogen, A1=an amide (NHC(O)) or ester (OC(C)) bond, OPO(OM)2, where M=an alkyli or alkyli earth metal, OP(O)O−—O(CH2)2—N+(CH3)3, A2-(PEGX1-A3)n-R4, where n=0 or 1, PEGX1=a polyethyleneglycol of molecular weight X1, where X1 being less than or equal to 5,000 daltons, A2 and A3 independently=a ether (O), ester (OC(O)), amide (NHC(O)), urea (NHC(O)NH), thiourea (NHC(S)NH), or thioether (S) bond R4=a directing agent.

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