PROBLEM TO BE SOLVED: To provide substances or compositions promoting collagen production of cells.SOLUTION: The present invention provides a collagen production promoter consisting of a double stranded nucleic acid in which a first nucleic acid comprising the nucleic acid sequence described in the Sequence Listing table as SEQ ID NO:1 is complementarily bound to a second nucleic acid comprising the nucleic acid sequence described in the Sequence Listing table as SEQ ID NO:2.SELECTED DRAWING: NoneCOPYRIGHT: (C)2018,JPO&INPIT【課題】細胞のコラーゲン産生を促進する物質又は組成物を提供すること。【解決手段】本発明は、配列表の配列番号1で示される塩基配列を含む第1の核酸と、配列表の配列番号2で示される塩基配列を含む第2の核酸とが相補的に結合している二本鎖核酸からなるコラーゲン産生促進剤を提供する。【選択図】なし