Anti-egfr antibody drug conjugate formulations

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专利权人:

AbbVie Inc.;AbbVie Deutschland GmbH & Co. KG

发明人:

Vineet Kumar,Katharina Kaleta,Markus Tschoepe

申请号：

NZ63082614

公开号：

NZ630826A

申请日:

2014.03.14

申请国别(地区):

NZ

年份:

2017

代理人:

摘要：

Discloses lyophilized pharmaceutical formualtions comprising an anti-EGFR antibody drug conjugate (ADC). The antibody has the HCDR sequences of SEQ ID NO: 15-17 and the LCDRs of SEQ ID NO: 20-22 or the HCVR of SEQ ID NO: 13 and the LCVR of SEQ ID NO: 18. The auristatin can be monomethylauristatin F (MMAF). The formulation further comprises a sugar, histidine and a surfactant. In a further embodiment the formulation comprises sucrose, histidine and polysorbate 80.

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