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T CELL RECEPTORS
专利权人:
发明人:
SU QIN,MOLLOY PETER,LIDDY NATHANIEL
申请号:
IN201617004638
公开号:
IN201617004638A
申请日:
2016.02.09
申请国别(地区):
IN
年份:
2016
代理人:
摘要:
The present invention relates to T cell receptors (TCRs) which bind the HLA A2 restricted CLGGLLTMV peptide derived from the LMP2A protein from Epstein Barr Virus (EBV). TCRs of the invention comprise a TCR alpha chain variable domain and/or a TCR beta variable domain. Certain preferred TCRs also bind the natural peptide variants SLGGLLTMV and CLGGLITMV presented as a peptide HLA A2 complex. The TCRs of the invention demonstrate excellent specificity profiles for those LMP2A epitopes and have binding affinities for the complex which result in an enhanced ability to recognize the complex compared to a soluble reference TCR having the extracellular sequence of the native EBV LMP2A TCR alpha chain given in Figure 3 (SEQ ID No: 4) and the extracellular sequence of the native EBV LMP2A TCR beta chain given in Figure 4 (SEQ ID No: 5)
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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