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Novel mucosal adjuvants and delivery systems
专利权人:
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS
发明人:
Pumford, Neil,Shivaramaiah, Srichaitanya,Hargis, Billy,Morgan, Marion,Tellez, Guillermo,Wolfenden, Amanda
申请号:
NZ70806513
公开号:
NZ708065A
申请日:
2013.10.29
申请国别(地区):
NZ
年份:
2019
代理人:
摘要:
Adjuvants comprising chitosan cross-linked with, an aldehyde or mannosylated chitosan are provided herein. Methods of making the adjuvants and methods of combining or linking the adjuvants with antigens are also provided. The adjuvant-antigen combinations can be used in vaccine formulations and the vaccine formulations can be used, in methods to vaccinate animals against the source of the antigen or to enhance the immune response in a subject. A particular embodiment of the invention is a vaccine formulation comprising a microbial antigen and an adjuvant composition, the adjuvant composition comprising an open ring mannose moiety linked to chitosan to form a Schiff base, wherein the Schiff base is not reduced.
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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