A compound represented by the following formula, a salt thereof or a hydrate of the foregoing has an excellent hepatocyte growth factor receptor (HGFR) inhibitory activity, and exhibits anti-tumor activity, angiogenesis inhibitory activity and cancer metastasis inhibitory activity. [R 1 represents a 3- to 10-membered non-aromatic heterocyclic group or the like； R 2 and R 3 represent hydrogen； R 4 , R 5 , R 6 , and R 7 may be the same or different and each represents hydrogen, halogen, C 1-6 alkyl or the like； R 8 represents hydrogen or the like； R 9 represents a 3- to 10-membered non-aromatic heterocyclic group or the like； n represents an integer of 1 or 2； X represents -CH=, nitrogen or the like.]一般式；(I)；(式中，R1表示3~10員非芳香族雜環式基等。R2及R3表示氫原子。R4、R5、R6及R7表示相同或相異之氫原子、鹵素原子、C1-6烷基等。R8表示氫原子等。R9表示3~10員非芳香族雜環式基等。n表示1至2之整數。X表示式-CH=所示基或氮原子)所示化合物或其鹽或彼等之水合物的具有優良肝細胞增殖因子受體(HGFR)阻斷作用，且具有抗腫瘤作用、血管新生阻斷作用或癌細胞轉移抑制作用。
