A device for extracting unwanted material in a vascular conduit of a subject is provided in an embodiment herein. The device includes an elongate member including a proximal end and a distal end, the distal end for introduction into a vascular conduit of a subject. The device further includes a material engaging structure disposed at the distal end of the elongate member, the material engaging structure configured to expand to contact an inner surface of the vascular conduit to fragment and/or detach unwanted material in the conduit. A collection structure is disposed on the distal end of the device to collect the fragmented and/or detached unwanted material in the conduit for removal from the conduit.
