BEIGELMAN, LEONID,DEVAL, JEROME,WANG, GUANGYI,PRHAVC, MARIJA,SMITH, DAVID BERNARD,JEKLE, CHRISTIAN ANDREAS
申请号：
PE0004942016
公开号：
PE06582016A1
申请日:
2014.10.09
申请国别(地区):
PE
年份:
2016
代理人:
摘要：
Refers to Nucleosides, Nucleotides and nucleotide analogues of formula (i), or pharmaceutically acceptable salts of the sameIt is characterized because B1a is a Heterocyclic base optionally substituted with an amino Group protected, among others both are Absent (in Dashed Lines),Or both are a simple Link ra1 and RA2 are independently H or deuterium ra is H, alkyl c1\u2013c3, CN, among others 2a is H, alkyl, Halo, c1\u2013c4, among others and r5a is H, alkyl, Halo, Oh, c1\u2013c6,Among others.When both layers are Absent, Z1 is absent O1 is or1a, A1A is H, acyl amino acid o\u2013enlazado \u2013p (,, OR) (OH) 2, \u2013p (o) H (OH), among others R3A is H, Halo, Oh, among others and R4A is H, Oh,Halo, N3, NH2, among others. When both layers are a simple Link, Z1 is > P (o) - > P (S) Oh, among others O1 or R3A and R4 is or is H, Oh, NH2, Halo, N3, among others.It also relates to pharmaceutical compositions comprising such compounds of formula (i).The compounds of the invention are useful in the treatment of viral infections caused by picornaviruses and Flaviviridae.Se refiere a nucleosidos, nucleotidos y analogos de nucleotidos de formula (I), o sales farmaceuticamente aceptables de los mismos, que se caracterizan porque B1A es una base heterociclica opcionalmente sustituida con un grupo amino protegido, entre otros ambas lineas discontinuas (-----) estan ausentes, o ambas son un enlace simple Ra1 y Ra2 son independientemente H o deuterio RA es H, alquilo C1–C3, CN, entre otros R2A es H, halo, alquilo C1–C4, entre otros y R5A es H, halo, OH, alquilo C1–C6, entre otros. Cuando ambas ----- estan ausentes, Z1 esta ausente O1 es OR1A, donde R1A es H, acilo, aminoacido O–enlazado, –P(O)(OH)2, –P(O)H(OH), entre otros R3A es H, halo, OH, entre otros y R4A es H, OH, halo, N3, NH2, entre otros. Cuando ambas ----- son un enlace simple, Z1 es >P(O)OH, >P(S)OH, entre otros O1 es O R3A es O y R4 es H, OH, halo, N3, NH2, entre otros. Tambien se refiere a composiciones farmaceuticas que
