A method for treating a target vascular portion of a subject including: providing an angioplasty balloon system including a balloon, the balloon carrying a first polymer, a second polymer, and at least one active agent on a surface of the balloon, the at least one active agent being at least partially contained within at least one of the first polymer and the second polymer, wherein the first polymer and the second polymer having different stereoisoisomeric forms that can co-crystalize to form a stereocomplex between the first and second polymers positioning the balloon proximate the target vascular portion expanding the balloon to engage the target vascular portion thereby delivering at least a portion of the active agent to the target vascular portion and withdrawing the balloon from the subject.
