CODON OPTIMIZATION AND RIBOSOME PROFILING FOR INCREASING TRANSGENE EXPRESSION IN CHLOROPLASTS OF HIGHER PLANTS

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专利权人:

THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

发明人:

DANIELL, Henry

申请号：

USUS2017/023263

公开号：

WO2017/165320A1

申请日:

2017.03.20

申请国别(地区):

WO

年份:

2017

代理人:

摘要：

Methods for improving transgene expression in chloroplasts are disclosed along with improved transgenes so produced and methods of use thereof for the treatment of disease. Specifically, the methods comprising analyzing the native sequence of a nucleic acid encoding a protein of interest and replacing codons in said sequence with those preferentially used in psbA genes in chloroplasts in higher plants.Linvention concerne des procédés permettant daméliorer lexpression transgénique dans des chloroplastes, ainsi que les transgènes améliorés ainsi produits et leurs méthodes dutilisation pour le traitement dune maladie.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/