BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM;OREGON STATE UNIVERSITY
发明人:
GELLER, BRUCE L.,GREENBERG, DAVID
申请号：
CA2972653
公开号：
CA2972653A1
申请日:
2015.12.23
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
Provided are antisense oligonucleotides targeted against bacterial genes involved in biochemical pathways and/or cellular processes, and related compositions and methods of using the oligonucleotides and compositions, alone or in combination with other antimicrobial agents, for instance, in the treatment of an infected mammalian subject. Embodiment's of the present disclosure relate, in part, to the discovery that the antisense targeting of bacterial genes involved in biochemical pathways and/or cellular processes can, inter alia, increase the antibiotic susceptibility of otherwise antibiotic-resistant pathogenic bacteria, and reduce the ability of certain pathogenic bacteria to grow.
