PROBLEM TO BE SOLVED: To provide a new hypoglycemic substance; a new hypoglycemic substance having hypoglycemic activity based on a function other than a function related to insulin; and a hypoglycemic agent using the substance.SOLUTION: This hypoglycemic substance is a protein or a peptide comprising an amino acid sequence shown by (a) or (b): (a) an amino acid sequence shown by the sequence number 1 in a sequence table, (b) an amino acid sequence having ≥16% homology with the amino acid sequence shown by the sequence number 1 in the sequence table.