Compounds derived from 3 - methyl - 4 - 7 - oxo - tia - 1 - aza Bicyclo [3.2.0] heptane for use in inhibition of beta lactamase produced by bacteria and restore / enhance the activity of antibiotics and Pharmaceutical composition that comprises.
Described herein are compounds and their use in the treatment of infections. The compound of formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, solvates, pharmaceutically acceptable salts and pharmaceutical compositions described herein are also useful as beta-lactamase inhibitors, which restore or enhance the antibiotic spectrum of a suitable antibiotic agent. The compounds of formula (I) act as inhibitors of beta-lactamases. These compounds restore/potentiate the activities of beta-lactam antibiotics against carbapenemases. These compounds find use in diagnostic method for detecting beta-lactamases. Formula (I)USO DE UN COMPUESTO DERIVADO DE 3-METIL-7-OXO-4-TIA-1-AZA-BICICLO[3.2.0]HEPTANO, PARA EL TRATAMIENTO O PREVENCIÓN DE INFECCIÓN BACTERIAL QUE PRODUCE CARBAPENEMASA Y USO DEL COMPUESTO COMO REACTIVO DE DIAGNÓSTICO IN VITRO PARA DETECTAR CARBAPENEMASAS.
