An amphiphilic coating material for applying on at least a portion of one surface of an article comprises a copolymer containing one or more alkyl methacrylate or alkyl acrylate co-monomer units one or more vinyl acetate co-monomer units and up to 40% mole of polyethylene oxide substituted methacrylate co-monomer units. Optionally, one or more biologically active molecules may be covalently bonded to the polyethylene oxide substituted methacrylate co-monomer units.