The present invention relates to crystal forms of GFT-505 and a preparation method and use thereof. The provided crystal forms of GFT-505, CS1, CS2, CS5, and CS6, have high purities, good stabilities, low hygroscopicities, good solubilities, and high mechanical stabilities. The present invention provides a new and better choice for the preparation of a pharmaceutical preparation comprising the GFT-505 and is of great significance for drug development.