These compounds regulate the activity of PI3Ks and help to treat diseases related to PI3Ks activity, including inflammation, immune disorders, cancer and other diseases. Claim 1: a compound of formula (1) or a salt acceptable to the drug, wherein X is cr.83313 or N； W is cr8311 or N； and is cr831222；Or N； Z is a link or C (= O)；If - w = y-z-sea-cr-8311a = cr831222；-N = CR⁸-,-CR 3DCR -C (3DO) --N 3DCR -C (3DO) - o -CR 3DN-C (3DO) -R1 is lease No. c83217c83238a；R2 is halo, lease No. c1832131, lease No. 832626,C₁₋₆ alkoxy,C₁₋₆ haloalkyl,C₁₋₆ haloalkoxy,a. 5-6 members of phenyl or isopropene； 5-6 members of phenyl and isopropene are replaced by 1, 2, 3 or 4 substitutes selected separately from halogen；C₁₋₄ alkoxy and C₁₋₄ haloalkoxy；R es Cy - (alquilen C) -Cy halo CN NO1. Lease land No. c833218331 and 832626；C₂₋₆ alkenyl,1. C 83228331 asphalt；C₁₋₆ haloalkyl,Or7491,SR7491,C (3DO) RC (3DO) NR RC (3DO) OROC (3DO) ROC (3DO) NR RNo. 7580； No. 74966；No. 7580； (= O) r7495；No. 7580； (= O) or7495；NR C (3DO) NR RC (= No. 74977) r7495；C (= No. 74977)； r74966；Nr7580； (= No. 74979) nr758080；； r74966；NR S (3DO) RNR S (3DO) NR RS (3DO) R o S (3DO) NR Rwherein said C alquilo alkyl,a. R8308es h, halo, oh, CN, c8321ige c838333124；C₁₋₄ haloalkyl,C₁₋₄ alkoxy or C₁₋₄ haloalkoxy；R83099es halo, oh, CN, lease c8321c83318324；C₁₋₄ haloalkyl,C₁₋₄ alkoxy,C₁₋₄ haloalkoxy or cyclopropyl； R⁶ is H, halo, OH, CN, C₁₋₄ alkyl,C₁₋₄ haloalkyl,C₁₋₄ alkoxy or C₁₋₄ haloalkoxy；832431, rental block r831111h or c8332131；R⁸ is H, halo, -OH, -CN, C₁₋₆ alkyl,C₂₋₆ alkenyl,1. C 83228331 asphalt；C₁₋₆ haloalkyl,Scion- (rent C₁₋₃) -Cy²,Or7491.,7491；C (3DO) RC (3DO) NR RC (3DO) OROC (3DO) ROC (3DO) NR R7580； 749696；NR C (3DO) RNR C (3DO) ORNR C (3DO) NR RC (= No. 74977) r7495；； 2C (= 74977)； 7580； 274996；NR C (3DNR) NR RNR S (3DO) RNR S (3DO) NR RS (3DO) RS (= O) 8322； r7495； O S (= O) 8322； nr758080； r7496；； square；wherein said C alquilo alkyl,C₂₋₆ alkenyl,e. C831222； 7491es h, halo-cn, c83321218c8332626 asphalt；C₂₋
