A waterproof structure of endoscope joystick comprises: a substrate, on which a frame is configured an elastic cover having a first wall portion, wherein the elastic cover is disposed on the substrate and the first wall portion is sandwiched between the frame and the substrate a screw rod having a baffle portion, wherein one end of the screw rod is penetrated through the opening of the elastic cover and locked on the screw rod with a locking member, so that the screw rod may be fastened with the elastic cover.一種內視鏡搖桿防水結構包含有:一基板,上設有一框體。一彈性封套,具有一第一垣部,彈性封套設於基板上並且第一垣部被夾設於框體與基板之間。一螺桿,具有一擋板部,螺桿以一端穿設於彈性封套的開口,再以一鎖合件鎖合於螺桿上,使螺桿可以固定於彈性封套。10‧‧‧基板11‧‧‧貫孔20‧‧‧框體21‧‧‧頂面22‧‧‧底面23‧‧‧通孔29‧‧‧斜面30‧‧‧彈性封套31‧‧‧第一垣部311‧‧‧環狀肋40‧‧‧螺桿41‧‧‧擋板部
