PROCEDE DE PRODUCTION DE (1S,4S,5S)-4-BROMO-6-OXABICYCLO[3.2.1]OCTANE-7-ONE

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专利权人:

DAIICHI SANKYO COMPANY; LIMITED

发明人:

TAKAYANAGI, YOSHIHIRO,FURUYA, YUKITO,NAKAMURA, YOSHITAKA

申请号：

CA2896338

公开号：

CA2896338A1

申请日:

2014.03.28

申请国别(地区):

CA

年份:

2014

代理人:

摘要：

The present invention addresses the problem of providing a method for producing (1S,4S,5S)-4-bromo-6-oxabicyclo[3.2.1]octane- 7-one (1), which is important as an intermediate compound for the production of a FXa-inhibiting compound, with high efficiency. A method for producing (1S,4S,5S)- 4-bromo-6-oxabicyclo[3.2.1]octane-7-one (1), said method being characterized by treating a (R)-a-phenylethylamine salt of (S)-3-cyclohexene-1-carboxylic acid with 1,3-dibromo- 5,5-dimethylhydantoin or N-bromosuccinimide in a solvent.

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