ШАХ Саед М. (US),ХАССАН Дэниел (US),ХАССАН Сара (US)
申请号：
RU2013141534/15
公开号：
RU2013141534A
申请日:
2012.02.07
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A multi-particle composition of L-menthol, containing many particles having a reduced release under gastric conditions and increased release at a neutral pH, the particles containing: a core containing L-menthol as an active ingredient, wherein L-menthol is placed to the core in the form of at least 80% purified L-menthol material； an enteric coating on the core, while the enteric coating effectively releases at least about 80% L-menthol in about two hours and placed in an environment having a substantially neutral pH. 2. The composition according to claim 1, consisting of many particles, in which L-menthol is crystalline. The composition according to claim 2, consisting of many particles, in which crystalline L-menthol is present in the form of micronized particles. The composition according to claim 1, consisting of many particles, in which the core further comprises a solubilizing agent effective in solubilizing L-menthol. The composition according to claim 1, consisting of many particles, in which the core further comprises an antioxidant that effectively prevents the oxidation of L-menthol. The composition according to claim 5, consisting of many particles, in which the antioxidant is ascorbic acid. The composition according to claim 1, consisting of many particles, in which the core contains from about 30% to about 70% wt./mass. L-menthol. 8. The composition according to claim 1, consisting of many particles, in which the enteric coating contains a polymeric material having a glass transition temperature T of not more than about 30 ° C. The composition according to claim 1, consisting of many particles, in which an enteric coating1. Состоящий из множества частиц состав L-ментола, содержащий множество частиц, имеющих пониженное высвобождение в условиях желудка и повышенное высвобождение при нейтральном pH, при этом частицы содержат:сердцевину, содержащую L-ментол в качестве активного ингредиента, при этом L-ментол помещен в сердцевину в виде очищенного, по м
