您的位置: 首页 > 农业专利 > 详情页

PHARMACEUTICAL COMPOSITIONS WITHOUT CITRATE CONTAINING ANAKINRU
专利权人:
СВЕДИШ ОРФАН БИОВИТРУМ АБ (ПАБЛ) (SE)
发明人:
ФРАНССОН Йонас (SE),ФЛОРИН-РОБЕРТССОН Эбба (SE)
申请号:
RU2013141548/15
公开号:
RU2013141548A
申请日:
2012.02.09
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. A pharmaceutical composition suitable for injection containing an effective amount of anakinra and mannitol in an amount of 5 to 50 mg / ml, wherein said pharmaceutical composition does not contain citrate. The pharmaceutical composition according to claim 1, which is adapted for subcutaneous injection of anakinra. A pharmaceutical composition according to claim 1 or 2, wherein said effective amount of anakinra is from 20 to 200 mg / ml. A pharmaceutical composition according to claim 1 or 2, further comprising a chelating agent. 5. The pharmaceutical composition of claim 4, wherein said chelating agent is EDTA in an amount of 0.05 to 1 mM. A pharmaceutical composition according to claim 1 or 2, further comprising an emulsifier. The pharmaceutical composition of claim 6, wherein said emulsifier is a non-ionic surfactant Polysorbate 80 in an amount of from 0.01 to 1% .8. The pharmaceutical composition according to claim 7, containing 150 mg / ml anakinra, 0.5 mm EDTU and 0.1% Polysorbate 80.9. A pharmaceutical composition according to claim 1 or 2, further comprising a tonicity regulating agent in an amount sufficient to ensure isotonicity of the composition. The pharmaceutical composition of claim 9, wherein said tonicity control substance is NaCl in an amount of from 120 to 240 mM. The pharmaceutical composition of claim 9, wherein said tonicity regulating agent is a mixture of NaCl and a second tonicity regulating agent selected from the group consisting of monosaccharides, disaccharides and sugar alcohols. A pharmaceutical composition according to claim 1 or 2, not containing an additional buffering agent. The pharmaceutical composition according to claim 1 or 2, with1. Фармацевтическая композиция, приемлемая для инъекции, содержащая эффективное количество анакинры и маннит в количестве от 5 до 50 мг/мл, где указанная фармацевтическая композиция не содержит цитрата.2. Фармацевтическая композиция по п. 1, которая приспособлена для подкожной инъекции анакинры.3.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充