GRANZYME B PROTEASE VARIANTS

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专利权人:

发明人:

Stefan Barth,Sonja Schiffer,Grit Hehmann-Titt

申请号：

US15290812

公开号：

US20170051269A1

申请日:

2016.10.11

申请国别(地区):

US

年份:

2017

代理人:

摘要：

A polypeptide having a serine protease variant of the human granzyme B set forth by SEQ ID NO: 1, wherein the serine protease variant has at least 95% identity to SEQ ID NO: 1 and has a substitution at the position that corresponds structurally or by amino acid sequence homology to position Arg201 of SEQ ID NO: 1, and wherein the serine protease variant has activity to cleave the motif Ile-Glu-Thr-Asp.

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