UNIVERSITY OF MARYLAND, BALTIMORE;DAVILA, Eduardo;UNIVERSITY OF MARYLAND; BALTIMORE;TAMADA, Koji
发明人:
DAVILA, Eduardo,TAMADA, Koji
申请号：
USUS2011/064808
公开号：
WO2012/082841A9
申请日:
2011.12.14
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention provides a universal, yet adaptable, anti-tag chimeric antigen receptor (AT-CAR) system which provides T cells with the ability and specificity to recognize and kill target cells, such as tumor cells, that have been marked by tagged antibodies. As an example, &alpha；FITC-CAR-expressing T cells have been developed that specifically recognize various human cancer cells when those cells are bound by cancer-reactive FITC-labeled antibodies. The activation of &alpha；FITC-CAR-expressing T cells is shown to induce efficient target lysis, T cell proliferation, and cytokine/chemokine production. The system can be used to treating subjects having cancer.
