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Universal anti-tag chimeric antigen receptor-expressing T cells and methods of treating cancer
专利权人:
University of Maryland; Baltimore
发明人:
Davila, Eduardo,Tamada, Koji
申请号:
AU2011343887
公开号:
AU2011343887A1
申请日:
2011.12.14
申请国别(地区):
AU
年份:
2013
代理人:
摘要:
The present invention provides a universal, yet adaptable, anti-tag chimeric antigen receptor (AT-CAR) system which provides T cells with the ability and specificity to recognize and kill target cells, such as tumor cells, that have been marked by tagged antibodies. As an example, αFITC-CAR-expressing T cells have been developed that specifically recognize various human cancer cells when those cells are bound by cancer-reactive FITC-labeled antibodies. The activation of αFITC-CAR-expressing T cells is shown to induce efficient target lysis, T cell proliferation, and cytokine/chemokine production. The system can be used to treating subjects having cancer.
来源网站:
中国工程科技知识中心
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