The present invention is directed to therapeutic compounds, treatment method and kit, does not influence the nerve fiber in the channels NCCa-ATP, including neuron, neuroglia and blood vessel are in nervous system, and use its method. The NCCa-ATP channels newly express nerve such as ischaemic after injury, and it is to inhibit to pass through diazoxiide for example, glibenclamide and tolbutamide are opened by sulfonyl urea compound that adjusting, which is by sulfonylurea receptor SUR1,. NCCa-ATP channel antagonists, including SUR1 antagonists, it can be used for preventing, reduce, with the nerve fiber for the treatment of injury or illness, including astroglia, neuron and capillary endothelial cells, i.e., due to ischaemic, tissue damage, Brain edema and brain or spinal cord disease or the injury for increasing organizational stress or other forms. The agonist in the channels NCCa-ATP can be used for treating nerve fiber and damage or destroying the tissue, such as gliotic capsules are desired.
