FORMULATIONS STABLES DE POLYPEPTIDE

• 收藏
• 分享

专利权人:

AMGEN INC.

发明人:

REHDER, DOUGLAS,BONDARENKO, PAVEL,CHELIUS, DIRK,MCAULEY, ARNOLD,MATSUMURA, MASAZUMI

申请号：

CA2666492

公开号：

CA2666492C

申请日:

2007.10.05

申请国别(地区):

CA

年份:

2012

代理人:

摘要：

The invention provides a formulation including a buffer having a pH less than 6.0, a divalent cation between about 5-200 mM, an excipient comprising a sugar or polyol and an effective amount of a therapeutic polypeptide. Also provided is a method of stabilizing a polypeptide. The method includes contacting a therapeutic polypeptide with a concentration of divalent cation between about 5-150 150 mM in a buffer having a pH less than 6.0 and an excipient comprising a sugar or polyol.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/