Zepp, Charles,Lipford, Grayson B.,Gao, Yun,Johnston, Lloyd,Fu, Fen-ni,Keegan, Mark J.,Baldwin, Sam
申请号：
AU2017200388
公开号：
AU2017200388A1
申请日:
2017.01.20
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
#$%^&*AU2017200388A120170209.pdf#####Abstract This invention relates to compositions, and related compounds and methods, of conjugates of immunomodulatory agents and polymers or unit(s) thereof. The conjugates may be contained within synthetic nanocarriers, and the immunomodulatory agents may be released from the synthetic nanocarriers in a pH sensitive manner. See Fig. 1.WO 2010/138194 PCT/US2010/001561 1/5 % R848 Release (All) PBS, 37C 100.00 V 80.00 - 1 w U1 60.00 + 2 cc 40.00 -- 3 -N- 4 c. 20.00 +- 5 0.00 0 20 40 60 80 100 120 Hours FIG. 1 % R848 Release (All) Citrate, pH 4.5, 37C 120.00 a 100.00 80.00 -. W- 2 60.00 4. 40.00 ；. 4 0.00 - 5 0 20 40 60 80 100 120 6 Hours I 7 FIG. 2
