#$%^&*AU2017203307A120170608.pdf#####ABSTRACT This invention relates, at least in part, to osmotic mediated release barrier-free synthetic nanocarriers and methods of production and use. See Fig. 2.WO 2012/135010 PCT/US2012/030314 45% *n 44~ 35% ..E o 30% 4-1 00 20% 15% 0 S10% -'5% 0% 0 100 200 300 400 Calculated Osmolality (mOsm/kg) Fig. 1 Release Medium Osmolality (mOsm/kg) Fig. 2 1/1