ПРОИЗВОДНЫЕ ФЕНИЛСУЛЬФАМОИЛБЕНЗАМИДОВ В КАЧЕСТВЕ АНТАГОНИСТОВ БРАДИКИНИНОВЫХ РЕЦЕПТОРОВ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ИХ СОДЕРЖАЩАЯ
The present invention relates to new sulfonamide derivatives of formula (I)wherein R1 is hydrogen atom or C1-C4 alkyl group R2 is selected from (1) hydrogen atom (2) C1-C6 straight or branched alkyl group (3) -(CH2)n-NH2 (4) -(CH2)n-OH (5) -(CH2)n-CO-NH2 (6) benzyl optionally substituted with hydroxy group or halogen atom or R1, R2 and the carbon atom to which they are both attached together form a 3-7 membered cycloalkyl ring R3 is (1) hydrogen atom, (2) C1-C8 straight or branched alkyl group, optionally substituted with one or more substituents independently selected from amino, hydroxy, 1H-imidazol-4-yl, -NRaRb, -COORc, -NH-C(=NH)-NH2, -CO-NH2 group R4 is (1) hydrogen atom, (2) -(CH2)n-NRaRb group (3) -(CH2)m-X-P group R5, R6 and R7 are independently of each other hydrogen atom, halogen atom, cyano, nitro, amino, or amino substituted with one or more C1-C4 alkyl group trifluoromethyl C1-C4 alkoxy or trifluoromethoxy R8 is hydrogen atom or C1-C4 alkyl group Z is selected from (1) single bond (2) oxygen atom (3) CH2 group (4) CO group (5) NRc group n is an integer from 0 to 6 m is an integer from 0 to 6 X is selected from (1) single bond or CO P is selected from (1) phenyl group, optionally substituted with -(CH2)m-CN, -O-CO-NRcRc, -NH-CO-Rc, [l,4]bipiperidinyl-yl or -(CH2)n-NH-C(=NH)-NH2 group (2) a saturated, partially unsaturated or aromatic 4-7 membered ring containing 1-3 heteroatom selected from O, S and N wherein said ring is optionally substituted with one or more halogen atom, trifluoromethyl, -NH-CO-Rc, -C(=NH)-NH2, C1-C4 alkyl, pyridin-4-yl, piperidin-1-yl (3) a system consisting of saturated or aromatic 9 membered bicyclic ring containing 1-2 heteroatom selected from O, S and N wherein said ring system is optionally substituted with one or more halogen atom, (4) C5-C8 cycloalkyl group, optionally substituted with -(CH2)m-NRaRb group Ra and Rb are (1) hydrogen atom (2) straight or branched C1-C6 alkyl group (3) Ra, Rb and the nitrogen atom to which they
