RÉACTION DE PRINS ET D'INTERMÉDIAIRES UTILES DANS LA SYNTHÈSE DE MACROLIDES D'HALICHONDRINE ET DE SES ANALOGUES

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专利权人:

Eisai R&D Management Co.; Ltd.

发明人:

CHASE, Charles, E.,CHOI, Hyeong-Wook,ENDO, Atsushi,FANG, Francis, G.,KIM, Dae-Shik

申请号：

EP17821400

公开号：

EP3478691A4

申请日:

2017.06.30

申请国别(地区):

EP

年份:

2020

代理人:

摘要：

The invention provides methods for the synthesis of a halichondrin macrolides or analogs thereof through a cyclization reaction strategy. The strategy of the present invention involves subjecting an intermediate to Prins reaction conditions to afford a macrolide. The invention also provides compounds useful as intermediates in the synthesis of a halichondrin macrolides or analogs thereof and methods for preparing the same.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/