NATIONAL CANCER CENTER;CHUGAI SEIYAKU KABUSHIKI KAISHA
发明人:
MITSUNAGA, SHUICHI,光永修一,OCHIAI, ATSUSHI,落合淳志
申请号：
TW098118678
公开号：
TWI528973B
申请日:
2009.06.05
申请国别(地区):
TW
年份:
2016
代理人:
摘要：
The present inventors discovered that neural invasion is suppressed by inhibiting IL-6 in a model for neural invasion of pancreatic cancer, and completed the present invention. The present inventors also demonstrated that: an IL-6 receptor is expressed in cells of human pancreatic cancer cell lines； and IL-6 enhances the chemotactic and migratory activities and intracellular signaling of pancreatic cancer cells； and thus pancreatic cancer can be treated by inhibiting IL-6. Furthermore, the present inventors found that neural invasion of human pancreatic cancer can be suppressed, from the results of administering IL-6 inhibitors to neural invasion model mice.本發明發現胰臟癌神經浸潤模式中，藉由抑制IL-6而抑制神經浸潤。而且確定人胰臟癌細胞株表現IL-6受體，及IL-6增進胰臟癌細胞的趨化能力、移動能力及細胞內訊息，發現抑制IL-6可治療胰臟癌。再者，藉由投予小鼠神經浸潤模式IL-6抑制劑，發現可抑制人胰臟癌的神經浸潤。
