NATIONAL CANCER CENTER;CHUGAI SEIYAKU KABUSHIKI KAISHA
发明人:
MITSUNAGA, SHUICHI,OCHIAI, ATSUSHI
申请号：
EP09758415
公开号：
EP2305306A4
申请日:
2009.06.05
申请国别(地区):
EP
年份:
2012
代理人:
摘要：
The present inventors discovered that neural invasion is suppressed by inhibiting IL-6 in a model for neural invasion of pancreatic cancer, and completed the present invention. The present inventors also demonstrated that: an IL-6 receptor is expressed in cells of human pancreatic cancer cell lines； and IL-6 enhances the chemotactic and migratory activities and intracellular signaling of pancreatic cancer cells； and thus pancreatic cancer can be treated by inhibiting IL-6. Furthermore, the present inventors found that neural invasion of human pancreatic cancer can be suppressed, from the results of administering IL-6 inhibitors to neural invasion model mice.
