Lutz Weber,Vladimir Khazak,Günther F Ross,Cotïc Kalinski,Christoph Burdack
申请号：
US11909014
公开号：
US08163744B2
申请日:
2006.03.17
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention provides a compound selected from compounds of formula I as ligand binding to the HDM2 protein, inducing apoptosis and inhibiting proliferation, and having therapeutic utility in cancer therapy. Compounds of formula (I) can be used as therapeutics for treating stroke, myocardial infarction, ischemia, multi-organ failure, spinal cord injury, Alzheimers Disease, injury from ischemic events, heart valvular degenerative disease Moreover, compounds of formula (I) can be used to decrease the side effects from cytotoxic cancer agents and to treat viral infections.
