WU, WEN-LIAN,吴文连,吳文連,BURNETT, DUANE A.,伯奈特 杜安A,伯奈特 杜安A,STAMFORD, ANDREW W.,史丹佛 安德鲁W,史丹佛 安德魯W,CUMMING, JARED N.,卡门 杰瑞N,卡門 傑瑞N,BENNETT, CHAD EDWARD,班尼特 查德 艾德华,班尼特 查德 艾德華,GILBERT, ERIC J.,吉伯特 艾力克J,吉伯特 艾力
申请号：
TW101123606
公开号：
TW201311680A
申请日:
2012.06.29
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
In its many embodiments, the present invention provides provides certain iminothiazine compounds and mono- and dioxides thereof, including compounds Formula (I): and tautomers and stereoisomers thereof, and pharmaceutically acceptable salts of said compounds, said tautomeros and said stereoisomers, wherein each of the variables shown in the formula are as defined herein. The novel compounds of the invention may be useful as BACE inhibitors and/or for the treatment and prevention of various pathologies related thereto. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use, including Alzheimer’s disease, are also disclosed.在本發明之多個實施例中,本發明提供某些亞胺噻化合物及其一氧化物及二氧化物,其包括式(I)化合物:及其互變異構體及立體異構體,及該等化合物、該等互變異構體及該等立體異構體之醫藥上可接受之鹽,其中該式中所顯示之每一變量係如本文中所定義。本發明之該等新穎化合物可用作BACE抑制劑及/或用於治療及預防與其相關之各種病狀。本發明亦揭示包含一或多種該等化合物(單獨及與一或多種其他活性劑組合)之醫藥組合物,及其製備及使用方法,包括阿茲海默氏病(Alzheimers disease)。
