Jason Katz,James Jewell,Joon Jung,Solomon Kattar,Yongquan Hou,Rachel MacCoss,Satoru Ito
申请号：
US13057325
公开号：
US08455477B2
申请日:
2009.07.27
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention relates to pyrazolopyridines and imidazopyridines which are inhibitors of the kinase PDK1 and are thus useful for the treatment of myeloproliferative disorders or cancer. The compounds are also useful as inhibitors of other kinases such as FGFR3, NTRK3, RP-S6K and WEE1. Furthermore, the present compounds also selectively inhibit microtubule affinity regulating kinase (MARK) and are therefore useful for the treatment or prevention of Alzheimer's disease.
