METHODS OF PRODUCING GENETICALLY-MODIFIED EUKARYOTIC CELLS WITH RATIONALLY-DESIGNED MEGANUCLEASES

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专利权人:

Homme W. HELLINGA;Derek JANTZ;James J. SMITH

发明人:

James J. SMITH,Derek JANTZ,Homme W. HELLINGA

申请号：

US13532190

公开号：

US20120266266A1

申请日:

2012.06.25

申请国别(地区):

US

年份:

2012

代理人:

摘要：

Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.

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