James Jefferson Smith,Derek Jantz,Homme W. Hellinga
申请号：
US16570623
公开号：
US20200109383A1
申请日:
2019.09.13
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
