Prema Vijayakumar;Ronald Harding;Phoebe Sun;Albert Zorko Abram;Maria Graziella Larm;Michael Johnston
发明人:
Maria Graziella Larm,Ronald Harding,Michael Johnston,Albert Zorko Abram,Prema Vijayakumar,Phoebe Sun
申请号：
US11216668
公开号：
US08460641B2
申请日:
2005.08.31
申请国别(地区):
US
年份:
2013
代理人:
摘要：
An oil-in-water microemulsion or sub-micron emulsion composition for dermal delivery of at least one pharmaceutically active ingredient, comprising: a first part including at least one occlusive agent and one or more lipophilic surfactants dispersed throughout a second part including water and at least one hydrophilic surfactant, and a non-surfactant amphiphilic type compound, pharmaceutically active ingredient, and water. It has been found that if a non-surfactant amphiphilic type compound is added together with the second part as would conventionally be the case, a microemulsion or sub-micron emulsion is not formed, by adding the so called third part, phase assembly occurs at a lower temperature than would be expected and moreover, this phase appears to assist in maintaining the microemulsion or sub-micron emulsion characteristics of the formulation during storage at normal temperatures.
