Leo Jacobus Jozef Backx;Lieven Meerpoel;Peter Ten Holte;Guuske Frederike Busscher
发明人:
Lieven Meerpoel,Leo Jacobus Jozef Backx,Peter Ten Holte,Guuske Frederike Busscher
申请号：
US12446581
公开号：
US08158783B2
申请日:
2007.10.22
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention is concerned with novel tetrahydro-naphthalene-1-carboxylic acid derivatives having apoB secretion/MTP inhibiting activity and concomitant lipid lowering activity. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of atherosclerosis, pancreatitis, obesity, hypertriglyceridemia, hypercholesterolemia, hyperlipidemia, diabetes and type II diabetes. Formula (I).
