MEERPOEL, LIEVEN,BACKX, LEO JACOBUS JOZEF,TEN HOLTE, PETER,BUSSCHER, GUUSKE FREDERIKE
申请号：
CA2664143
公开号：
CA2664143C
申请日:
2007.10.22
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The present invention is concerned with novel tetrahydro-naphthalene-1-carboxylic acid derivatives having apoB secretion/MTP inhibiting activity and concomitant lipid lowering activity. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of atherosclerosis, pancreatitis, obesity, hypertriglyceridemia, hypercholesterolemia, hyperlipidemia, diabetes and type II diabetes. Formula (I).
