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Antibody that binds to il-4 or il-13 and /
专利权人:
SANOFI
发明人:
ERCOLE, RAO,VINCENT, MIKOL,DANXI, LI,JOCHEN, KRUIP,MATTHEW, DAVISON
申请号:
TR201810005
公开号:
TR201810005T4
申请日:
2008.10.14
申请国别(地区):
TR
年份:
2018
代理人:
摘要:
On Humanized Antibodies or Antibody Fragments that bind to il-4 or il-13, which comprise a light chain variable SEC sec id id no. 3 and no. 1, respectively, and a heavy chain variable selected from the group consisting of sec id no. 4, no. 5 sec SEC ID or ID no. 2 re Spectivamente. Also includes CH1, CH2 and CH3 Domains, a constant region.Also refers to a Bi specific bi specific Antibody or Antibody fragment that binds to il-13 and il-4, which comprises a light chain variable SEC ID no. 1 and no. 3, and a heavy chain variable SEC ID no. 2 and no. 4, where these sequences are United with a Linker peptide Also, includes Domains CH1, CH2 and CH3 a constant region.These Antibodies are conjugated with an additional effector Molecule as heterologous polypeptides, Drugs and toxins, radionuclides. It also relates to a Pharmaceutical composition that comprises a Nucleic Acid encoding Antibodies, a Vector and a host cell. To be useful for the treatment of Asthma and allergic dermatitisElimizdeki buluş özgün insanlaştırılmış anti-IL-4 ve IL-13 antikorları ve bunların kısımları ve spesifik olarak IL-4 ve IL-13'e bağlanan özgün bispesifik antikorlar ve bunların kısımları ile ilintilidir. Buluş aynı zamanda allerjik astım ve dermatit de dahil olmak üzere IL-4 ve/veya IL-3 aracılıklı hastalık ya da rahatsızlıkların tedavi edilmesi ve önlenilmesinde antikorların kullanımını ihtiva etmektedir.
来源网站:
中国工程科技知识中心
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