RAO ERCOLE,MIKOL VINCENT,LI DANXI,KRUIP JOCHEN,DAVISON MATTHEW
申请号：
NZ60134208
公开号：
NZ601342A
申请日:
2008.10.14
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
601342 Disclosed is a bispecific antibody or bispecific antibody fragment thereof that specifically binds to IL-13 and IL4, wherein: the bispecific antibody or bispecific antibody fragment thereof comprises two light chains and two heavy chains； the light chains comprise an outer variable light chain domain linked to an inner variable light chain domain which is linked to a constant light chain domain (CL), and the heavy chains comprise an outer variable heavy chain domain linked to an inner variable heavy chain domain which is linked to a constant heavy chain domain (CH1)； the bispecific antibody or bispecific antibody fragment thereof has a higher affinity for IL-13 and/or IL-4 than the antibody from which the variable light chain or variable heavy chain domain or complementarity determining regions (CDRs) were derived； and (e) the outer variable light chain domain comprises the amino acid sequences RASESVDSYGQSYMH (CDR1； SEQ ID NO: 8), LASNLES (CDR2； SEQ ID NO: 9), and QQNAEDSRT (CDR3； SEQ ID NO: 10), the inner variable light chain domain comprises the amino acid sequences HASQNIDVWLS (CDR1； SEQ ID NO: 14), KASNLHTG (CDR2； SEQ ID NO: 15), and QQAHSYPFT (CDR3； SEQ ID NO: 16), the outer variable heavy chain domain comprises the amino acid sequences GFSLTDSSIN (CDR1； SEQ ID NO: 11), DGRID (CDR2； SEQ ID NO: 12), and DGYFPYAMDF (CDR3； SEQ ID NO: 13), and the inner variable heavy chain domain comprises the amino acid sequences GYSFTSYWIH (CDR1； SEQ ID NO: 17), IDPSDGETR (CDR2； SEQ ID NO: 18), and LKEYGNYDSFYFDV (CDR3； SEQ ID NO: 19)； (f) the outer variable light chain domain comprises the amino acid sequences RASESVDSYGQSYMH (CDR1； SEQ ID NO: 8), LASNLES (CDR2； SEQ ID NO: 9), and QQNAEDSRT (CDR3； SEQ ID NO: 10), the inner variable light chain domain comprises the amino acid sequences HASQNIDVWLS (CDR1； SEQ ID NO: 14), KASNLHTG (CDR2； SEQ ID NO: 15), and QQAHSYPFT (CDR3； SEQ ID NO: 16), the outer variable heavy chain domain comprises the amino acid sequences GFSLTDSSIN
