A bone screw and bone plate apparatus with multiple screwing directions includes a substance, a positioning adjustment ring and a bone screw. The substance has a coupling hole. The positioning adjustment ring is mounted in the coupling hole of the substance. The positioning adjustment ring has a engaged portion. The positioning adjustment ring includes a first adjustment member and a second adjustment member. One end of the first adjustment member connects to one end of the second adjustment member. The bone screw has a adjustment portion coupled to the engaged portion of the positioning adjustment ring.