Guy Dequesne,Sophie Marie Jeanne Valentine Germain
申请号：
US13388715
公开号：
US20120189650A1
申请日:
2010.08.03
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to ClfA polypeptides wherein amino acid Y474 or an amino acid adjacent to Y474 is mutated such that fibrinogen binding activity is decreased compared to an equivalent ClfA polypeptide without mutation of Y474 or an amino acid adjacent to Y474 as well as immunogenic compositions, vaccines, processes and uses of such mutated ClfA polypeptides.
