Richard W. Titball,Sérgio Paulo Fernandes Da Costa,Claire Naylor,Ajit Basak
申请号：
US14354117
公开号：
US09422343B2
申请日:
2012.10.24
申请国别(地区):
US
年份:
2016
代理人:
摘要：
There is provided a NetB epitope polypeptide comprising at least 10 contiguous amino acids from SEQ ID NO:1 and comprising a mutation in at least one position between amino acids 130 and 297 as compared with the equivalent position in SEQ ID NO:3, the mutation preferably being located within a rim domain, the polypeptide being capable of binding an antibody which binds to SEQ ID NO:1 and having reduced toxicity compared with the toxicity of SEQ ID NO:1. The polypeptide is useful to vaccinate a subject against infection by Clostridium perfringens.
