A chorionic gonadotropin carboxy terminal peptide (CTP)-modified polypeptide comprising a growth hormone for use in a method of reducing the dosing frequency of a growth hormone in a human adult subject, wherein the CTP-modified polypeptide comprises one chorionic gonadotropin carboxy terminal peptide (CTP) attached to the amino terminus of the growth hormone, and two chorionic gonadotropin CTPs attached to the carboxy terminus of the growth hormone, and optionally a signal peptide attached to the amino terminus of the amino terminal CTP, wherein the method comprises administering to the subject a therapeutically effective amount of the CTP-modified polypeptide.
