The present invention relates to a nano-particle composition prepared by a process which is characterized by dissolving a poorly-soluble compound in water under high temperature and high pressure, cooling the resulting solution to prepare a suspension comprising a uniform crystal thereof, and crushing the suspension.本發明係有關一種奈米粒子組成物,其係藉由下述方法獲得:在高溫、高壓下使難溶性化合物溶解於水等,將所得的溶液冷卻以獲得含有均勻結晶之懸浮液等,並將該懸浮液等進行破碎。