RICHARDS, GARETH,SKERRY, TIMOTHY M.,HARRITY, JOSEPH P.A.,ZIRIMWABAGABO, JEAN-OLIVIER,TOZER, MATTHEW J.,GIBSON, KARL RICHARD,PORTER, RODERICK ALAN,BLANEY, PAUL MATTHEW,GLOSSOP, PAUL ALAN
申请号：
CA3063809
公开号：
CA3063809A1
申请日:
2018.05.16
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts thereof: (I) wherein R1, R2, R3, R4, R5, R6, R8, R9, X, X1, X2, X3, L1 and n are as defined herein. The compounds are inhibitors of adrenomedullin receptor subtype 2 (AM2). Also disclosed are the compounds for use in the treatment of diseases modulated AM2, including proliferative diseases such as cancer； pharmaceutical compositions comprising the compounds； methods for preparing the compounds；and intermediates useful in the preparation of the compounds.
